Adverse drug interactions in dental practice: interactions involving antibiotics. Part II of a series.
Identifieur interne : 000546 ( Main/Exploration ); précédent : 000545; suivant : 000547Adverse drug interactions in dental practice: interactions involving antibiotics. Part II of a series.
Auteurs : E V Hersh [États-Unis]Source :
- Journal of the American Dental Association (1939) [ 0002-8177 ] ; 1999.
Descripteurs français
- KwdFr :
- Antagonistes GABA (pharmacocinétique), Antagonistes GABA (pharmacologie), Antibactériens (effets indésirables), Antibactériens (pharmacocinétique), Antibactériens (pharmacologie), Anticoagulants (pharmacocinétique), Anticoagulants (pharmacologie), Antifongiques (effets indésirables), Antifongiques (pharmacocinétique), Antifongiques (pharmacologie), Antihistaminiques des récepteurs H1 (pharmacocinétique), Antihistaminiques des récepteurs H1 (pharmacologie), Antituberculeux (pharmacologie), Biodisponibilité (MeSH), Contraceptifs oraux (antagonistes et inhibiteurs), Digoxine (pharmacocinétique), Digoxine (pharmacologie), Digoxine (sang), Femelle (MeSH), Humains (MeSH), Hypnotiques et sédatifs (pharmacocinétique), Hypnotiques et sédatifs (pharmacologie), Inhibiteurs des enzymes du cytochrome P-450 (MeSH), Interactions médicamenteuses (MeSH), Lithium (pharmacologie), Lithium (sang), Soins dentaires (MeSH), Vitamine K (métabolisme), Éthanol (pharmacologie).
- MESH :
- antagonistes et inhibiteurs : Contraceptifs oraux.
- effets indésirables : Antibactériens, Antifongiques.
- métabolisme : Vitamine K.
- pharmacocinétique : Antagonistes GABA, Antibactériens, Anticoagulants, Antifongiques, Antihistaminiques des récepteurs H1, Digoxine, Hypnotiques et sédatifs.
- pharmacologie : Antagonistes GABA, Antibactériens, Anticoagulants, Antifongiques, Antihistaminiques des récepteurs H1, Antituberculeux, Digoxine, Hypnotiques et sédatifs, Lithium, Éthanol.
- sang : Digoxine, Lithium.
- Biodisponibilité, Femelle, Humains, Inhibiteurs des enzymes du cytochrome P-450, Interactions médicamenteuses, Soins dentaires.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (adverse effects), Anti-Bacterial Agents (pharmacokinetics), Anti-Bacterial Agents (pharmacology), Anticoagulants (pharmacokinetics), Anticoagulants (pharmacology), Antifungal Agents (adverse effects), Antifungal Agents (pharmacokinetics), Antifungal Agents (pharmacology), Antitubercular Agents (pharmacology), Biological Availability (MeSH), Contraceptives, Oral (antagonists & inhibitors), Cytochrome P-450 Enzyme Inhibitors (MeSH), Dental Care (MeSH), Digoxin (blood), Digoxin (pharmacokinetics), Digoxin (pharmacology), Drug Interactions (MeSH), Ethanol (pharmacology), Female (MeSH), GABA Antagonists (pharmacokinetics), GABA Antagonists (pharmacology), Histamine H1 Antagonists (pharmacokinetics), Histamine H1 Antagonists (pharmacology), Humans (MeSH), Hypnotics and Sedatives (pharmacokinetics), Hypnotics and Sedatives (pharmacology), Lithium (blood), Lithium (pharmacology), Vitamin K (metabolism).
- MESH :
- chemical , adverse effects : Anti-Bacterial Agents, Antifungal Agents.
- chemical , antagonists & inhibitors : Contraceptives, Oral.
- chemical , blood : Digoxin, Lithium.
- chemical , metabolism : Vitamin K.
- chemical , pharmacokinetics : Anti-Bacterial Agents, Anticoagulants, Antifungal Agents, Digoxin, GABA Antagonists, Histamine H1 Antagonists, Hypnotics and Sedatives.
- chemical , pharmacology : Anti-Bacterial Agents, Anticoagulants, Antifungal Agents, Antitubercular Agents, Digoxin, Ethanol, GABA Antagonists, Histamine H1 Antagonists, Hypnotics and Sedatives, Lithium.
- Biological Availability, Cytochrome P-450 Enzyme Inhibitors, Dental Care, Drug Interactions, Female, Humans.
Abstract
BACKGROUND
The prudent use of antibiotics is an integral part of dental practice. While these agents generally are considered safe in the dental setting, their use can result in interactions that can lead to serious morbidity in dental patients.
METHODS
The faculty of a symposium entitled "Adverse Drug Interactions in Dentistry: Separating the Myths From the Facts" did an extensive literature review on drug interactions. Through this, they were able to establish a significance rating of alleged adverse drug interactions as they relate to dentistry, based on their scientific documentation and severity of effect. The author of this article focused on antibiotics.
RESULTS
Most of the reported drug interactions discussed in this article are well-documented by clinical studies. It is particularly important that dentists be aware of the potentially serious and life-threatening interactions of the antibiotics erythromycin, clarithromycin and metronidazole, and of the antifungal agents ketoconazole and itraconazole, with a host of other drugs whose metabolism is impaired by these antimicrobial agents. In contrast, the alleged ability of commonly employed antibiotics to reduce the effectiveness of oral contraceptive agents is not adequately supported by clinical research. It still is recommended, however, that clinicians discuss this possible interaction with their patients, as it might represent a relatively rare event that cannot be discerned in clinical trials.
CONCLUSIONS
Potentially serious adverse drug interactions can occur between antimicrobial agents used in dental practice and other drugs patients are taking for a variety of medical conditions.
CLINICAL IMPLICATIONS
It is important that dentists stay abreast of potential drug interactions involving antibiotics to avoid serious morbidity among their patients.
DOI: 10.14219/jada.archive.1999.0173
PubMed: 10036847
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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(pharmacology)</term><term>Humans (MeSH)</term><term>Hypnotics and Sedatives (pharmacokinetics)</term><term>Hypnotics and Sedatives (pharmacology)</term><term>Lithium (blood)</term><term>Lithium (pharmacology)</term><term>Vitamin K (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antagonistes GABA (pharmacocinétique)</term><term>Antagonistes GABA (pharmacologie)</term><term>Antibactériens (effets indésirables)</term><term>Antibactériens (pharmacocinétique)</term><term>Antibactériens (pharmacologie)</term><term>Anticoagulants (pharmacocinétique)</term><term>Anticoagulants (pharmacologie)</term><term>Antifongiques (effets indésirables)</term><term>Antifongiques (pharmacocinétique)</term><term>Antifongiques (pharmacologie)</term><term>Antihistaminiques des récepteurs H1 (pharmacocinétique)</term><term>Antihistaminiques des récepteurs H1 (pharmacologie)</term><term>Antituberculeux (pharmacologie)</term><term>Biodisponibilité (MeSH)</term><term>Contraceptifs oraux (antagonistes et inhibiteurs)</term><term>Digoxine (pharmacocinétique)</term><term>Digoxine (pharmacologie)</term><term>Digoxine (sang)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hypnotiques et sédatifs (pharmacocinétique)</term><term>Hypnotiques et sédatifs (pharmacologie)</term><term>Inhibiteurs des enzymes du cytochrome P-450 (MeSH)</term><term>Interactions médicamenteuses (MeSH)</term><term>Lithium (pharmacologie)</term><term>Lithium (sang)</term><term>Soins dentaires (MeSH)</term><term>Vitamine K (métabolisme)</term><term>Éthanol (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Antifungal Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Contraceptives, Oral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Digoxin</term><term>Lithium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vitamin K</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Anticoagulants</term><term>Antifungal Agents</term><term>Digoxin</term><term>GABA Antagonists</term><term>Histamine H1 Antagonists</term><term>Hypnotics and Sedatives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Anticoagulants</term><term>Antifungal Agents</term><term>Antitubercular Agents</term><term>Digoxin</term><term>Ethanol</term><term>GABA Antagonists</term><term>Histamine H1 Antagonists</term><term>Hypnotics and Sedatives</term><term>Lithium</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Contraceptifs oraux</term></keywords><keywords 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scheme="MESH" xml:lang="en"><term>Biological Availability</term><term>Cytochrome P-450 Enzyme Inhibitors</term><term>Dental Care</term><term>Drug Interactions</term><term>Female</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biodisponibilité</term><term>Femelle</term><term>Humains</term><term>Inhibiteurs des enzymes du cytochrome P-450</term><term>Interactions médicamenteuses</term><term>Soins dentaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The prudent use of antibiotics is an integral part of dental practice. While these agents generally are considered safe in the dental setting, their use can result in interactions that can lead to serious morbidity in dental patients.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The faculty of a symposium entitled "Adverse Drug Interactions in Dentistry: Separating the Myths From the Facts" did an extensive literature review on drug interactions. Through this, they were able to establish a significance rating of alleged adverse drug interactions as they relate to dentistry, based on their scientific documentation and severity of effect. The author of this article focused on antibiotics.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Most of the reported drug interactions discussed in this article are well-documented by clinical studies. It is particularly important that dentists be aware of the potentially serious and life-threatening interactions of the antibiotics erythromycin, clarithromycin and metronidazole, and of the antifungal agents ketoconazole and itraconazole, with a host of other drugs whose metabolism is impaired by these antimicrobial agents. In contrast, the alleged ability of commonly employed antibiotics to reduce the effectiveness of oral contraceptive agents is not adequately supported by clinical research. It still is recommended, however, that clinicians discuss this possible interaction with their patients, as it might represent a relatively rare event that cannot be discerned in clinical trials.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Potentially serious adverse drug interactions can occur between antimicrobial agents used in dental practice and other drugs patients are taking for a variety of medical conditions.</p></div><div type="abstract" xml:lang="en"><p><b>CLINICAL IMPLICATIONS</b></p><p>It is important that dentists stay abreast of potential drug interactions involving antibiotics to avoid serious morbidity among their patients.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10036847</PMID><DateCompleted><Year>1999</Year><Month>03</Month><Day>03</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-8177</ISSN><JournalIssue CitedMedium="Print"><Volume>130</Volume><Issue>2</Issue><PubDate><Year>1999</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Journal of the American Dental Association (1939)</Title><ISOAbbreviation>J Am Dent Assoc</ISOAbbreviation></Journal><ArticleTitle>Adverse drug interactions in dental practice: interactions involving antibiotics. Part II of a series.</ArticleTitle><Pagination><MedlinePgn>236-51</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The prudent use of antibiotics is an integral part of dental practice. While these agents generally are considered safe in the dental setting, their use can result in interactions that can lead to serious morbidity in dental patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The faculty of a symposium entitled "Adverse Drug Interactions in Dentistry: Separating the Myths From the Facts" did an extensive literature review on drug interactions. Through this, they were able to establish a significance rating of alleged adverse drug interactions as they relate to dentistry, based on their scientific documentation and severity of effect. The author of this article focused on antibiotics.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Most of the reported drug interactions discussed in this article are well-documented by clinical studies. It is particularly important that dentists be aware of the potentially serious and life-threatening interactions of the antibiotics erythromycin, clarithromycin and metronidazole, and of the antifungal agents ketoconazole and itraconazole, with a host of other drugs whose metabolism is impaired by these antimicrobial agents. In contrast, the alleged ability of commonly employed antibiotics to reduce the effectiveness of oral contraceptive agents is not adequately supported by clinical research. It still is recommended, however, that clinicians discuss this possible interaction with their patients, as it might represent a relatively rare event that cannot be discerned in clinical trials.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Potentially serious adverse drug interactions can occur between antimicrobial agents used in dental practice and other drugs patients are taking for a variety of medical conditions.</AbstractText><AbstractText Label="CLINICAL IMPLICATIONS" NlmCategory="CONCLUSIONS">It is important that dentists stay abreast of potential drug interactions involving antibiotics to avoid serious morbidity among their patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hersh</LastName><ForeName>E V</ForeName><Initials>EV</Initials><AffiliationInfo><Affiliation>University of Pennsylvania, School of Dental Medicine, Department of Oral Surgery and Pharmacology, Philadelphia 19104-6003, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Am Dent Assoc</MedlineTA><NlmUniqueID>7503060</NlmUniqueID><ISSNLinking>0002-8177</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000925">Anticoagulants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000995">Antitubercular Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003276">Contraceptives, Oral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D065607">Cytochrome P-450 Enzyme Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018756">GABA Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006634">Histamine H1 Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006993">Hypnotics and Sedatives</NameOfSubstance></Chemical><Chemical><RegistryNumber>12001-79-5</RegistryNumber><NameOfSubstance UI="D014812">Vitamin K</NameOfSubstance></Chemical><Chemical><RegistryNumber>3K9958V90M</RegistryNumber><NameOfSubstance UI="D000431">Ethanol</NameOfSubstance></Chemical><Chemical><RegistryNumber>73K4184T59</RegistryNumber><NameOfSubstance UI="D004077">Digoxin</NameOfSubstance></Chemical><Chemical><RegistryNumber>9FN79X2M3F</RegistryNumber><NameOfSubstance UI="D008094">Lithium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000925" MajorTopicYN="N">Anticoagulants</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000995" MajorTopicYN="N">Antitubercular Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001682" MajorTopicYN="N">Biological Availability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003276" MajorTopicYN="N">Contraceptives, Oral</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065607" MajorTopicYN="N">Cytochrome P-450 Enzyme Inhibitors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003729" MajorTopicYN="Y">Dental Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004077" MajorTopicYN="N">Digoxin</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004347" MajorTopicYN="Y">Drug Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000431" MajorTopicYN="N">Ethanol</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018756" MajorTopicYN="N">GABA Antagonists</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006634" MajorTopicYN="N">Histamine H1 Antagonists</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006993" MajorTopicYN="N">Hypnotics and Sedatives</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008094" MajorTopicYN="N">Lithium</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014812" MajorTopicYN="N">Vitamin K</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>141</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>2</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>2</Month><Day>26</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>2</Month><Day>26</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10036847</ArticleId><ArticleId IdType="pii">S0002-8177(14)65718-4</ArticleId><ArticleId IdType="doi">10.14219/jada.archive.1999.0173</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Philadelphie</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Hersh, E V" sort="Hersh, E V" uniqKey="Hersh E" first="E V" last="Hersh">E V Hersh</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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